El trabajo doméstico y las labores domésticas se asocian, incluso hoy, con “lo femenino”, desde una perspectiva esencialista del género. Gracias a la obra de Beauvoir podemos indagar el género como una construcción social que asigna los roles y papeles que cada quien debe cumplir en una sociedad, para comenzar a señalar que la idea del “ama de casa de tiempo completo”, no es en absoluto una categoría que ha existido siempre, sino que está situada dentro de un contexto histórico (...) que sirvió para impulsar el desarrollo capitalista, como señala Silvia Federici. La perspectiva del feminismo materialista de Christine Delphy ofrece una crítica al marxismo clásico que ignora las condiciones de opresión y explotación de las mujeres. Presentamos un análisis sobre la manera en que el desarrollo del capitalismo y, al mismo tiempo, del patriarcado, ha atado a las mujeres a situaciones de violencia a partir de la dependencia económica. (shrink)

En este artículo analizo el contenido del libro _Freiheti_, publicado anónimo en 1791 y recientemente atribuido a la escritora Elise Reimarus (1735-1803). Se trata de una obra fundamental del periodo de la ilustración que, sin embargo, no ha recibido todavía suficiente atención por parte de los especialistas. Además de ofrecer una presentación del texto, examinar el estado de la cuestión y ofrecer un análisis del contenido del libro, incluyo la primera traducción al español del texto. Mi objetivo es mostrar que (...) al cumplir con su objetivo de definir qué es la libertad, Reimarus transmite un doble mensaje. Por un lado, la filósofa elogia la constitución de Hamburgo y llama a sus conciudadanos a obedecer las leyes que hacen posible la auténtica libertad. Por otro lado, se dirige a los príncipes de Europa para exhortarlos a introducir reformas en sus estructuras políticas que garanticen los derechos humanos, la igualdad y la justicia, además de defender la legitimidad de la revolución política, la necesidad de adoptar una forma democrática de gobierno y la libertad de pensamiento y expresión. Por todo ello, y teniendo en cuenta la manera en que los especialistas la definen, sostengo que Elise Reimarus puede ser considerada como una exponente de lo que se conoce como la Ilustración radical. (shrink)

It is a widely accepted idea that German Idealism stands on two pillars: Kant and Spinoza. The aim of this essay is to critically reflect on this way of understanding the history of philosophy through a study of the reception of Spinoza in the early writings of Fichte, Schelling, and Hegel. This analysis will show that each of them builds a different image of Spinoza that is not based on the scholarly study of his works, but rather deeply conditioned by (...) other readings and controversies of the time. Each assigns a central role to that image of Spinoza in the justification of his own system, and in each case that theoretical function is different: Spinoza is viewed as an enemy (Fichte), a possibility and a source of inspiration (Schelling), and a model of true philosophy (Hegel). (shrink)

Resumen: La noción de tópos, concebido como un principio compartido por una comunidad, desempeña una función central en los tratados de retórica desde la Antigüedad grecolatina. Este concepto también resulta relevante, creemos, en el discurso literario y permite trazar relaciones entre literatura y retórica. Si bien la literatura comparada le asigna autonomía al término y tiende a disociarlo de su función persuasiva, entendemos que los tópicos desempeñan en la comedia antigua una función compleja: operan como motivos literarios, pero también adoptan (...) a la vez una finalidad argumentativa. La comedia de Aristófanes, en particular, propugna ciertas ideas políticas, empleando varios tópicos, ya sea bajo la forma de enunciados o de personajes-tipo. Los tópicos se utilizan, entonces, tanto en la oratoria como en la comedia con fines persuasivos.: The notion of tópos, conceived as a principle shared by a community, has a central place in the treatises of rhetoric from Greco-Roman antiquity. This concept is also relevant, we believe, in literary discourse and it allows to establish a connections between literature and rhetoric. While comparative literature tends to disassociate this notion from its persuasive function, we understand that the tópoi have a complex function in ancient comedy: the tópoi are literary motifs, but also adopt an argumentative purpose. Aristophanes' comedy, in particular, advocates certain political ideas, using a series of tópoi, either in the form of statements or character types. The tópoi are then used in both oratory and comedy with persuasive purposes. (shrink)

Este trabajo se propone demostrar que el personaje de Demóstenes cumple un papel central dentro de la estrategia persuasiva de la pieza, que intenta degradar la imagen pública de Cleón. En las obras tempranas, el héroe cómico suele ser el principal portavoz de la postura defendida en la obra; sin embargo, en Caballeros la imagen del héroe, el Morcillero, resulta al principio tan devaluada que debilita la fuerza argumentativa del ataque; en este sentido, Demóstenes actúa como un héroe provisorio y (...) un portavoz autorizado del enunciador-autor hasta que el Morcillero alcanza legitimidad y verdadera estatura heroica. This paper aims to demonstrate that the character of Demosthenes plays a central role in the persuasive strategy of the piece, which attempts to degrade the public image of Cleon. In the early works, the comic hero is usually the main spokesperson who defends the position maintained in the work; however, the image of the hero in Knights, the Sausage-Seller, is so devaluated at first that the argumentative force of the attack becomes weak; in this sense, Demosthenes acts as a provisional hero and authorized spokesman for the enunciatorauthor until the Sausage-Seller reaches more legitimacy and true heroic stature. (shrink)

Resumen: Esta nota crítica analiza la perspectiva que Martha Nussbaum presenta sobre la emoción de la ira en su último libro Anger and Forgiveness. Resentment, Generosity, Justice. Para ello sitúo esta obra en el contexto del proyecto filosófico de la autora y señalo algunos cambios y continuidades en su análisis de la ira; después reviso a la luz de este nuevo libro algunas de las críticas que, centradas en la reivindicación de la ira, ha recibido su propuesta de una cultura (...) política centrada en las emociones “humanizadoras”.: This critical note examines Martha Nussbaum’s perspective on anger presented in her last book Anger and Forgiveness. Resentment, Generosity, Justice. I place this book in the context of Nussbaum’s philosophical project in order to trace changes and continuities in her views on anger, and then I examine some criticisms that have been held against her proposal of a political culture based on humanizing emotions based on the vindication of anger. (shrink)

The essays in this volume present the first comprehensive account of Fichte’s reception and influence in America, highlighting philosophical issues central to thinkers in the U.S., Argentina, Brazil, and Mexico.

This article focuses on Spinoza’s conception of philosophy. Based on what is stated on On the Improvement of the Understanding and the Theologico-Political Treatise, we propose that Spinoza does not consider philosophy as an already possessed knowledge, but as the pursuit of truth, closely linked to the pursuit of happiness. Philosophy is, according to this conception, a practice that involves the process by which human beings become free of prejudices and errors that prevent them from apprehending truth, and that hinder (...) their thought and their action. This path of self emancipation of error is, according to our proposal, the authentic spirit of philosophy according to Spinoza, what, as we will show, is explicitly expressed in certain passages of his Ethics. (shrink)

Este artículo propone un análisis de los Aforismos sobre religión y deísmo escritos por J. G. Fichte en 1790, poco antes de su conversión a la filosofía kantiana. Sostenemos que este texto no expresa la adhesión de Fichte al determinismo, ni al punto de vista del corazón, ni tampoco se limita a presentar la religión y el deísmo como dos sistemas opuestos. Según nuestra interpretación, Fichte defiende dos tesis. En primer lugar, que la mezcla de ambos sistemas es inaceptable y (...) hay que respetar el límite que existe entre ellos. En segundo lugar, que es imposible sostener ninguno de los dos sistemas, porque necesariamente entran en colisión y dejan al ser humano en una situación de desgarramiento. La conclusión del fragmento es, por lo tanto, la necesidad de buscar una posición superadora, que logre subsanar la escisión. Esa posición superadora será la Doctrina de la ciencia, que modifica los términos del planteo antagónico y logra la reconciliación de la libertad y la filosofía. This article proposes an analysis of the Aphorisms on Religion and Deism written by J. G. Fichte in 1790, shortly before his conversion to the Kantian philosophy. We argue that this text does not express Fichte’s accordance with determinism, or with the point of view of the heart, nor merely present religion and deism as two opposing systems. According to our interpretation, Fichte defends two theses. First, that the mixture of both systems is unacceptable and the limit between them must be respected. Secondly, that it is impossible to affirm neither of them, because they necessarily collide and leave the human being in a situation of scission. The conclusion of the fragment is, therefore, the need to seek a position that overcomes this situation of scission. That position will be the Doctrine of science, which amends the antagonistic terms of the dilemma and achieves the reconciliation between freedom and philosophy. (shrink)

Se trata de una reseña del libro de Ricardo Ibarlucía. Belleza sin aura: Surrealismo y teoría del arte en Walter Benjamin, Buenos Aires, Miño y Dávila, 2020, 434 páginas.

En los últimos años, la relación entre la filosofía de la Ilustración y el cinismo ha logrado atraer la atención de los especialistas. En ese marco, los críticos suelen identificar las filosofías de Diógenes y Diderot. El objetivo del presente trabajo es revisar el vínculo que existe entre ambos con el fin de demostrar que el mismo es problemático y que, por esa razón, desborda las interpretaciones que se han presentado hasta el momento. Esto, por otra parte, arrojará luces sobre (...) la relación entre el materialismo de Diderot y su teoría ético-política. In recent years the relationship between the philosophy of the Enlightenment and cynicism has managed to attract the attention of scholars. In this framework, critics often identify Diogenes and Diderot's philosophy. The aim of this paper is to examine the relationship between Diderot and Diogenes in order to demonstrate that it is a problematic relationship that goes beyond the interpretations that have been presented so far. This, on the other hand, will shed light on the relationship between Diderot's materialism and his ethical and political theory. (shrink)

Experiential imagination consists in an imaginative projection that aims at simulating the experiences one would undergo in different circumstances. It has been traditionally thought to play a role in how we build our lives, engage with other agents, and appreciate art. Although some philosophers have recently expressed doubts over the capacity of experiential imagination to offer insight into the perspective of someone other than our present-selves, experiential imagination remains a much sought-after tool. This paper substantiates pessimism about the epistemological value (...) of these uses of experiential imagination by developing an embodied approach. Our thesis is that experiential imagination is _robustly embodied_ because the _sociohistorically situated_ body makes an irreducible contribution to the imaginative project, and that, as such, it is constrained by who we are as _concrete_ agents. We argue that experiential imagination is an embodied, virtual exploration of imagined scenarios that depends on our situated history of sensorimotor and affective interactions. We conclude that experiential imagination is much more limited than commonly acknowledged, as it can hardly be divorced from who we are and where we have been. (shrink)

It has been pointed out that Sensorimotor Enactivism, a theory that claims that perception is enacted and brought about by movement, says very little about the neural mechanisms that enable perception. For the proponents of the predictive approach to Sensorimotor Enactivism, this is a challenge that can be met by introducing predictive processing into the picture. However, the compatibility between these theories is not straightforward. Firstly, because they seem to differ in their stand towards representations: while Sensorimotor Enactivism is said (...) to belong to the non-representational wing of cognitive science, predictive processing has a representational profile. And secondly, because they exhibit different explanatory strategies: while Sensorimotor Enactivism prioritizes the interactions of the embodied agent, predictive processing has internalist commitments. The aim of this paper is to address these concerns and show that a predictive approach to Sensorimotor Enactivism is viable. More specifically, I focus on the Free-Energy approach, a theory that falls within the ballpark of predictive processing. In this paper I argue for the following claims. I argue that both Sensorimotor Enactivism and the Free-Energy approach may be understood for some systems in representational terms. The non-representational reading of Sensorimotor Enactivism is not mandatory and neither is the representational reading of the Free-Energy approach. Sensorimotor Enactivism is, in this respect, compatible with both representational and non-representational interpretations of the FEA. So, the position towards representations of these frameworks should not stand in the way of a predictive approach to Sensorimotor Enactivism. I also show that the Free-Energy approach allows for an account that prioritizes the interaction of the embodied agent with the environment. This is the explanatory strategy followed by Sensorimotor Enactivism. To justify this strategy and following other proponents of Sensorimotor Enactivism, I argue that by referring to the interactions of the embodied agent a better account of the phenomena in question is provided. On this basis, I claim that Sensorimotor Enactivism and the Free-Energy approach are compatible in what concerns their explanatory strategy as well. Thus, making the case for the viability of the predictive approach to Sensorimotor Enactivism. (shrink)

In ‘Rethinking Nature: Phenomenology and a Non-reductionist Cognitive Science’, Gallagher [2019] sets out to overcome resistance to the idea that phenomenology is relevant to cognitive science. He argues that the relevance in question may be secured if we rethink the concept of nature. For Gallagher, this transformed concept of nature—which is to be distinguished from the classic scientific conception of nature in that it embraces irreducible subjectivity—is already at work in some contemporary enactive phenomenological approaches to cognitive science. Following a (...) summary of Gallagher’s argument, we argue that this rethinking of nature is not necessary to secure the aim in question. We articulate two alternative ways of achieving the relevance of phenomenology to cognitive science. The first, which turns on a minimal notion of naturalism, leaves the classic scientific conception of nature intact. The second, which turns on a practice-based analysis of collaboration between phenomenology and cognitive science, leaves it open which concept of nature one should adopt. As we show, each of the proposals on the table (Gallagher’s own and our two alternatives) comes at a cost. Which of the three proposals is the more attractive will depend on which cost one wants to pay. (shrink)

During the project of the fundamental ontology, Heidegger refers to destruction as a moment of phenomenology –among other two that are equally constitutive– which has a mainly historical character. Now, this paper aims to show that the notion of philosophy as destruction is intensified as Heidegger’s thought moved forward. Destruction, in Heidegger’s first lectures, demands an analysis on both the limits and possibilities of the philosophical tradition. It is in this analysis when we come to realize that the question of (...) being has been forgotten; that, instead of that, we have privileged the question of beings. In this way, destruction allows us to discover the absence of Being and, therefore, the horizon from which it must be answered: time. On the lectures that came after Being and Time, Heidegger shows that the absence unveiled by the destructive analysis is based on the character of Dasein itself. This being is constituted by the absence of beings, by nothing. Philosophy is, therefore, destruction in the most radical way, because its task is to show the metaphysical character of Dasein. It is only because of this task that philosophy in this destructive manner is historical. (shrink)

Richard Shusterman. Ars Erotica: Sex and Somaesthetics in the Classical Arts of Love. Cambridge: Cambridge University Press, 2021, 420 páginas. Yanina Benitez (ed.). Intersecciones. Reelaboraciones de la filosofía contemporánea y la estética filosófica. Porto: Cravo, 2020, 395 páginas.

This paper analyses the phenomenology and epistemology of chatbots such as ChatGPT and Bard. The computational architecture underpinning these chatbots are large language models (LLMs), which are generative artificial intelligence (AI) systems trained on a massive dataset of text extracted from the Web. We conceptualise these LLMs as multifunctional computational cognitive artifacts, used for various cognitive tasks such as translating, summarizing, answering questions, information-seeking, and much more. Phenomenologically, LLMs can be experienced as a “quasi-other”; when that happens, users anthropomorphise them. (...) For most users, current LLMs are black boxes, i.e., for the most part, they lack data transparency and algorithmic transparency. They can, however, be phenomenologically and informationally transparent, in which case there is an interactional flow. Anthropomorphising and interactional flow can, in some users, create an attitude of (unwarranted) trust towards the output LLMs generate. We conclude this paper by drawing on the epistemology of trust and testimony to examine the epistemic implications of these dimensions. Whilst LLMs generally generate accurate responses, we observe two epistemic pitfalls. Ideally, users should be able to match the level of trust that they place in LLMs to the degree that LLMs are trustworthy. However, both their data and algorithmic opacity and their phenomenological and informational transparency can make it difficult for users to calibrate their trust correctly. The effects of these limitations are twofold: users may adopt unwarranted attitudes of trust towards the outputs of LLMs (which is particularly problematic when LLMs hallucinate), and the trustworthiness of LLMs may be undermined. (shrink)

Elizabeth Anker y Bernardette Meyler, profesoras de literatura y de derecho respectivamente, involucradas ambas en los últimos años con el movimiento “derecho y literatura”, editan en 2017 New Directions in Law and Literature.

Este artículo está basado en un metaanálisis sobre la producción bibliográfica, nacionale internacional, referida al clima institucional en los institutos educativos y surelación con el desempeño laboral de los docentes, en los últimos años (2015-2022).Se ha llevado a cabo una revisión sistemática según las directrices PRISMA. La búsquedase llevó a cabo en las bases de datos Web of Science, EBSCO, Scopus y en el sitioweb Scholar Google. Los análisis metaanalíticos se realizaron a través del softwaregratuito JAMOVI y los complementos del (...) programa MAJOR y ESCI. (shrink)

_Resumen. _Este artículo tiene como objetivo principal caracterizar la violencia político electoral en el departamento de Santander tras la firma del Acuerdo de Paz en Colombia. Para ello se analiza la violencia en el marco de los procesos electorales de 2018 y 2019 a partir de dos dimensiones analíticas: 1) violencia contra políticos y/o candidaturas, liderazgos y periodistas y; 2) delitos electorales en contextos de violencia armada. El análisis se llevó a cabo a partir de la revisión de indicadores de (...) las bases de datos de instituciones gubernamentales y no gubernamentales. Los resultados evidencian que la violencia político electoral en el departamento aumentó en las elecciones regionales de 2019, que la “amenaza” es el hecho victimizante más recurrente, que las principales víctimas son los líderes y lideresas sociales y que la corrupción al sufragante es el delito electoral más denunciado en zonas de influencia de los grupos armados. (shrink)

A questão "se uma elocução perde seu significado com a destruição das coisas "surge como uma questão sobre o valor-verdade de declarações com um termo vazio como sujeito, a saber, como um subproblema do sofisma "Se 'omnis homo de necessitate est animal' é verdade quando não há homem algum ". Neste trabalho, trarei as discussões conforme elas se apresentam em "De signis" IV.2 de Roger Bacon, em "Quaestiones logicales", q. 2–3 de Peter John Olivi, no OHNEA de Boethius of Dacia, (...) e no OHNEA de Anonymus Alani. Tais textos nos apresentam quatro modos diversos de nos relacionarmos com a questão sobre significação para OHNEA e, assim, com quatro posições diferentes sobre a relação entre significação e referência vazia. Usarei Anonymus Alani como o fio conductor de minha análise, inserindo outras posições onde tal se fizer relevante.The question 'whether an utterance loses its signification with the destruction of things ' is raised as a question about the truth-value of assertions with an empty term as a subject, namely as a sub-problem of the sophism 'Whether "omnis homo de necessitate est animal" is true when no man exists '. In this paper, I shall introduce the discussions as they are present in Roger Bacon's "De signis" IV.2, Peter John Olivi's "Quaestiones logicales", q. 2–3, Boethius of Dacia's OHNEA, and Anonymus Alani's OHNEA. These texts present us with four different ways of relating the question about signification to OHNEA, and therefore with four different positions regarding the relation between signification and empty reference. I shall use Anonymus Alani as the guiding thread of my analysis, inserting other positions where it is relevant. (shrink)

Philosophy has long either dismissed or paid only minimal attention to creativity, and even with the rise of research on imagination, the creative imagination has largely been ignored as well. The aim of this volume is to correct this neglect. By bringing together existing research in various sub-disciplines, we also aim to open up new avenues of research. The chapters in Part I provide some framing and history on the philosophical study of imagination and creativity, along with an overview of (...) the empirical literature. Part II explores imagination and creativity as they manifest in, and in turn shape, the individual. Part III surveys the role of imagination and creativity across a wide variety of artistic domains, and the chapters of Part IV turn to societal domains. Part V focuses on the interplay of imagination and creativity with regard to particular features of creative subjects and different kinds of creative subjects. *** -/- Part I: Theories and Approaches 1. Theories of Imagination (Peter Kung) 2. Theories of Creativity (Julia Langkau) 3. Historical Treatments of Imagination in the Western Tradition (Lucia Oliveri) 4. Historical Treatments of Creativity in the Western Tradition (Elliot Paul) 5. Non-Western Treatments of Imagination (Reza Hadisi and Jing Iris Hu) 6. Non-Western Treatments of Creativity (Nicolas B. Verger and Vlad Glăveanu) 7. Empirical Treatments of Imagination and Creativity (Dustin Stokes) 8. Experimental Philosophy of Imagination and Creativity (Michael T. Stuart) 9. The Relationship between Imagination and Creativity (Margherita Arcangeli) -/- Part II: Imagination and Creativity in Mind and Action 10. Imagination, Creativity, and Skill (Amy Kind) 11. Imagination, Creativity, and Attention (Bence Nanay) 12. Imagination, Creativity, and Agency (Caterina Moruzzi) 13. Imagination, Creativity, and Emotion (Julien Deonna and Fabrice Teroni) 14. Imagination, Creativity, and Embodiment (Adriana Clavel-Vázquez and María Jimena Clavel Vázquez) 15. Imagination, Creativity, and Gender (Luke Roelofs) 16. Imagination, Creativity, and Race (Nicholas Whittaker) 17. Imagination, Creativity, and Child Development (Thalia Goldstein, Anna Sofia Caruso, Darian Stapleton, and Lamin Fatty) -/- Part III: Imagination and Creativity in the Arts 18. Imagination, Creativity, and the Visual Arts (Claire Anscomb) 19. Imagination, Creativity, and Music (Matteo Ravasio) 20. Imagination, Creativity, and Fiction (Hannah H. Kim) 21. Imagination, Creativity, and Dance (David Davies and Anna Pakes) 22. Imagination, Creativity, and the Culinary Arts (Patrik Engisch) 23. Imagination, Creativity, and Film (Murray Smith) 24. Imagination, Creativity, and Acting (Tzachi Zamir) 25. Imagination, creativity, and fashion (Laura T. Di Summa) -/- Part IV: Imagination and Creativity in Society 26. Imagination and Creativity in the Scientific Realm (Alice Murphy) 27. Imagination and Creativity in the Moral Realm (Tim Mulgan) 28. Imagination and Creativity in the Political Realm (Avshalom Schwartz) 29. Imagination and Creativity in the Law (Maksymilian Del Mar) 30. Imagination and Creativity in the Religious Realm (Neil Van Leeuwen) 31. Imagination and Creativity in Business (Eric Peterson) 32. Imagination and Creativity in Times of Crisis (Jennifer Fraser and Noah Stemeroff) Part V: Emerging Issues in Imagination and Creativity Research 33. Imagination, Creativity, and Aphantasia (Andrea Blomkvist) 34. Imagination, Creativity, and Neurodivergence (Sofia Ortiz-Hinojosa) 35. Imagination, Creativity, and Non-Human Animals (Henry Shevlin) 36. Imagination, Creativity, and Artificial Intelligence (Peter Langland-Hassan) 37. Collective Imagination and Collective Creativity (Nick Wiltsher) . (shrink)

In lieu of an abstract, here is a brief excerpt of the content:James K. Mish'alani KAFKA: TEXT'S BODY, BODY'S TEXT LONG BEFORE it appears in its own life as a bio-anatomical object, the body itself is integrally lived; and after it makes its appearance, lying or standing there ready for scrutiny, dissection, examination, it yields itself thus in its objectivity only to kindred bodily probing, wherein the hands that search, press, palpate and die roving eyes, the patient, closeheld ear, are (...) not encountered, but lived as modes of access to their object. Generally, the lived body is for itself transcendence toward the world as that within which diings are to be met, and the world, disclosed in an implicit understanding of what things one can behave toward and how one can variously behave toward diem, thus stands in correspondence to the body. As limit, die world determines the specific ways in which things are to be dealt with. As access, the body on its side projects through the lived articulation of limbs and organs those paths toward, by and about things whereby die very complexion ofdie world is always revealed. The body is world-revelation. ] But as die presence of diings in the lighting of revelation is not uniform or indifferent, but variegated, so is die body differentiated, articulated, variously organed and limbed, outfitted, equipped, and geared. The window lets in the light ofday and opens out on scenes only for die seeing eyes of a creature of vistas and distances. The hammer, standing out toward nails and wood, as toward all that they may be nailed togedier for and all diat diey may be brought togedier from, does so only insofar as it is ready for die hand diat lifts it. The pair of shoes suited to the earth, gathering about it die doorsill to die country path, the windswept fields, sun, rain, grain, bread, evening, dawn, die hearth and floorboards by childbed or deadibed, does all this in its humble reliability for the tread of the peasant woman whose footedness releases her through it to the security of a simple world. Thejug mat comes to full presence asjug in the outpouring ofa gift 56 James K. Mish'alani57 in which, be it water or wine, earth and sky together dwell by a marriage of soil and rock to rain and sun in spring or vine — this jug does its manifold-simple gathering of the world's extremities for the hand that pours the outpour, toward the lips for whom a refreshing drink is given, or before the faces lifted up in thanks to the gods for whom a libation is poured.2 Thus are things in most essential ways rooted in the body; and as primal ground the body in turn remains matrix to the world, not an object found in it.3 Nor does the other's body appear in the manner of an object in my encounter with him or her, whose features, glances, gestures, and movements all point beyond themselves and thus turn me with them toward that which occupies them and in relation to which I must assume a specific stance if only to reject it or, deciding it does not concern me, pass it by. The other's body lights up the world for me no less than mine does, in a co-transcendence toward a common horizon of meaning consensually confirmed, and ever renewed, laying for us a shared ground of world engagement without which even error, disagreement, and dissension become impossible. As the equipment through which I ordinarily pass in my projects does not stand out as an object until it breaks or is lost, so the other's body and mine do not obtrude and call attention to themselves in pure anatomical objectivity unless a radical breakdown occurs occasioned by some such disruption as disease, death, or a chaos of incoordination. Otherwise and until then, the other and I continue to be co-workers at world-disclosure, passing through each other's attitudes and movements as through unobstructed space. The human shape that comes toward me from the opposite direction reveals that part ofmy path I have left behind. The open hand thrust out from that tattered sleeve... (shrink)

Eukaryotic genomes harbor a large number of homologous repeat sequences that are capable of recombining. Their potential to disrupt genome stability highlights the need to understand how homologous recombination processes are coordinated. The Saccharomyces cerevisiae Rad1–Rad10 endonuclease performs an essential role in recombination between repeated sequences, by processing 3′ single‐stranded intermediates formed during single‐strand annealing and gene conversion events. Several recent studies have focused on factors involved in Rad1–Rad10‐dependent removal of 3′ nonhomologous tails during homologous recombination, including Msh2–Msh3, Slx4, and (...) the newly identified Saw1 protein. Together, this new work provides a model for how Rad1–Rad10‐dependent end processing is coordinated: Msh2–Msh3 stabilizes and prepares double‐strand/single‐strand junctions for Rad1–Rad10 cleavage, Saw1 recruits Rad1–Rad10 to 3′ tails, and Slx4 mediates crosstalk between the DNA damage checkpoint machinery and Rad1–Rad10. (shrink)

La instauración del sistema penal acusatorio en varios países de Latinoamérica ha enfrentado el reto, entre muchos, de configurar nuevos estándares para la actuación judicial. Este artículo se centra en el reto que representa para los juzgadores valorar la confiabilidad de la prueba científica, dado que su naturaleza excede el conocimiento de la mayoría de ellos. Evaluar la confiabilidad y corrección de la prueba científica para asignarle un peso específico en el acervo probatorio es una labor para la que el (...) juez requiere de un análisis multidisciplinario. A manera de guía para el juzgador y como una herramienta innovadora en el ambiente judicial latinoamericano, se proponen lineamientos generales y específicos a seguir en la valoración de la confiabilidad de la prueba en tres áreas forenses. (shrink)

Airway mucin secretion is important pathophysiologically and as a model of polarized epithelial regulated exocytosis. We find the trafficking protein, SNAP23, selectively expressed in secretory cells compared with ciliated and basal cells of airway epithelium by immunohistochemistry and FACS, suggesting that SNAP23 functions in regulated but not constitutive epithelial secretion. Heterozygous SNAP23 deletant mutant mice show spontaneous accumulation of intracellular mucin, indicating a defect in baseline secretion. However mucins are released from perfused tracheas of mutant and wild-type mice at the (...) same rate, suggesting that increased intracellular stores balance reduced release efficiency to yield a fully compensated baseline steady state. In contrast, acute stimulated release of intracellular mucin from mutant mice is impaired whether measured by a static imaging assay 5 min after exposure to the secretagogue ATP or by kinetic analysis of mucins released from perfused tracheas during the first 10 min of ATP exposure. Together, these data indicate that increased intracellular stores cannot fully compensate for the defect in release efficiency during intense stimulation. The lungs of mutant mice develop normally and clear bacteria and instilled polystyrene beads comparable to WT mice, consistent with these functions depending on baseline secretion that is fully compensated. (shrink)